Merry Christmas and Happy New Year

Merry Christmas and Happy New Year.

Thanks team from this great year. Team is growing and crunching. That's why the team was created. Crunch for good cause and making the world a better place for our kids.

LTDAkiles

Please join "My efforts against Childhood Cancer" Team at Malariacontrol.net

 Please Join our teams last crunching rush of 2011 at Malariacontrol.net.

What is malariacontrol.net?

The malariacontrol.net project is an application that makes use of network computing for stochastic modelling of the clinical epidemiology and natural history of Plasmodium falciparum malaria.

Simulation modeling of malaria

The fight against malaria was given a new impetus by the call for eradication at the Gates Malaria Forum in October 2007, making more but still limited resources available for research, development, and combating malaria. To inform decisions on which new or existing tools to prioritize, we have developed a general platform for comparing, fitting, and evaluating stochastic simulation models of Plasmodium falciparum malaria, programmed in C++ (openmalaria).

We use this to inform the target product profiles for novel interventions like vaccines, addressing questions such as minimal efficacy and duration of effects needed for a vaccine to be worthwhile, and also to optimize deployment of established interventions and integrated strategies. Field trials of interventions consider effects over 1-2 years at most, but the dynamics of immunity and human demography also lead to longer term effects. We consider many different outcomes, including transmission reduction or interruption, illness, hospitalization, or death, as well as economic aspects.

Malaria occurs in an enormous variety of ecological settings, and interventions are not always universally applicable. For instance, indoor residual spraying works only with indoor-resting mosquitoes, and insecticide treated mosquito nets only with nocturnal vectors. The best combinations of interventions vary, as do optimal delivery approaches and their health system implications. There are trade-offs between high coverage and costs or feasibility of deployment. Indiscriminate deployment may lead to evolution of drug resistance or insensitivity to other interventions. To support the analysis of these elements we are assembling databases of health system descriptions, intervention costing, and vector bionomics across different malaria ecotypes.

Uncertainties inherent in simulations of complex systems are addressed using probabilistic sensitivity analyses, fitting multiple different models, and basing predictions on model ensembles not single simulations. This requires super-computing, both for statistical fitting (which must simultaneously reproduce a wide range of outcomes across different settings), and for exploring predictions. We obtain this computing power over the internet from spare capacity on the computers of volunteers (malariacontrol.net).

Meetings with potential users of these predicitons are used to promote the models and their predictions to wider communities of malariologists, planners, and policy specialists. We are also developing web-based job submission and analysis systems to increase internet access to models.
This project is supported by

 You can join here after adding project to your Boinc Manager :http://www.malariacontrol.net/team_display.php?teamid=3333

"My efforts against childhood cancer" Team Captain is user of the day @Moo!wrapper!

   "My efforts against childhood cancer" Team Captain is user of the day @ Moo!Wrapper
Because of this honor i have ordered AMD Sapphire 6950 for Moo!Wrapper Boinc crunching.
Hopefully this new gpu will generate more points and get more work done for our Boinc team "My efforts against childhood cancer". Hopefully our team will interest new boincers to join our Boinc team.

Please join My efforts against childhood cancer  Moo!Wrapper team.

If you are interested about Boinc, want more information or don't know Boinc project just for you, please email Akiles@windowslive.com and i'm happy to help.

Thank you
LTDAkiles

Waiting for Radeon HD 7950 / 7970 / 7990 and Nvidia "Kepler" 28nm

   We "crunchers" will soon get nice new gpus to crunch with. Interesting times again.
I will get most likely at least new AMD HD 7950 or 7970 and maybe Nvidia "Kepler" if it will offer good performance vs Price with good energy efficiency. Let's hope AMD and Nvidia will release quality gpus with equal performance. In that case we the consumers will win, because of the price competition. Hopefully AMD will be strong at Folding@Home and Boinc crunching.

Superlink@Technion

  Superlink@Technion helps geneticists all over the world find disease-provoking genes causing some types of diabetes, hypertension (high blood pressure), cancer, schizophrenia and many others.

   Superlink@Technion helps geneticists perform genetic linkage analysis, which is a statistical method used to associate functionality of genes with their location on chromosomes. It typically serves for detecting mutated disease-provoking genes. This analysis can be extremely computationally intensive and has been parallelized for simultaneous execution on many computers. Geneticists submit the data for the analysis via Superlink-online linkage analysis portal. The tasks are then automatically parallelized and scheduled for execution on many computers in the Technion, in the University of Wisconsin in Madison, and also on many computers all over the world.


Your computer can help geneticists perform their analysis faster! All you need to do is download and install a small client, called BOINC. The client will start the computations according to the predefined scheduling policy, which by default is configured to start jobs only at nights and during weekends. The client will pull the data and the executable from our server, perform the computations and then return the results back to the server. The program that will perform the actual computations is called Superlink. It is a well known genetic linkage analysis program developed in our laboratory, and thoroughly tested to make sure that it cannot corrupt any local data. You will also be able to configure your BOINC client to restrict the use of your computer.

My efforts against childhood cancer Team have been created there.

"My efforts against childhood cancer" Team moves to top 4!!

   "My efforts against childhood cancer" Team takes 4th place (Boinc Finnish Team overall points).
Our team is getting good amount of work units done and we are gaining Top 3 daily.
Thanks goes to our great members.

   We need more new members to join and crunch with us for the good cause.
If you, your family members or/and friends are interested what we do or just want to use your computer idle time for good cause, Please Join "My efforts against childhood cancer" Team or if you have any questions about Boinc,crunching,hardware or installation i'm happy to help. Please email to Akiles@windowslive.com

22 days until Christmas!

    

   Only 22 days until Christmas. My kids can't wait for Santa Claus . In finnish Santa is Joulupukki, Christmas is Joulu and Rudolpf the Red nosed Reindeer is Petteri Punakuono. Let's make this Christmas special for the children.

Here is a place for the Christmas spirit. Santa Claus village
Photos are from SantaPark Arctic Circle Rovaniemi, Finland.

Here is a link for livecam feed from Santas office. You can see Santa working.

Making the World a better place for our kids by Donating cpu cycles!

The Help Fight Childhood Cancer comes to you from the Chiba Cancer Center Research Institute, which is affiliated to Chiba University, located in Chiba prefecture, Japan.

As the name of the project implies, the focus of this project is to try to find novel drugs to treat childhood cancers, namely neuroblastoma.

Neuroblastoma is one of the most frequently occurring solid tumors in children, especially in the first two years of their life, and its clinical outcome is still very poor. 

With your help, we hope to do the initial research which could result in discoveries that could lead to the development of novel drugs to treat these complex pediatric tumors.

Although, we expect to finish the project in about 2 years on World Community Grid, your contribution is appreciated as it would take us over 100 years on the computers available to us to finish this computation. Join now!

Latest News from The Help Fight Childhood Cancer project:


After screening 3,000,000 candidate chemicals by molecular imaging and cellular toxicity, our project team has finally identified 7 small chemical compounds which kill several neuroblastoma cells at very low concentration.

From: HFCC

My efforts against childhood cancer Team goes top 20 RAC at Collatz Conjecture!

My efforts against childhood cancer Team goes top 20 RAC at Collatz Conjecture!
You can check standings here!

Thank you team!

Cancer Wellness Programs: Recovery Through Fitness

Cancer Wellness Programs: Recovery Through Fitness 


   Exercise plays an important role in health and wellness programs, especially for those who have lost their health to cancer. Many cancer recovery programs focus on reclaiming health and wellness through exercise and meditation. They are always tailored to meet the needs of individual cancer patients. Just about anyone can benefit, from breast cancer survivors to those facing rare and trying mesothelioma treatment.

   Cancer wellness programs provide many of the same benefits other exercise programs offer -- better circulation, stronger muscles, and improved energy and stamina. But their benefits go beyond the physical. Cancer patients who engage in exercise experience a decreased isolation, for example, and a remarkable sense of empowerment.

Physical Benefits

   Many cancer patients view their fitness recovery programs as motivating and inspiring. They credit cancer wellness programs with helping them “get back into life,” at a time when it may be hard to get out of bed.

   Conventional treatments are proven to fight cancer aggressively. But patients are usually left with negative side effects, including pain, nausea; sleep problems, anxiety, and depression. Exercise helps patients tolerate treatment better, and it helps them sleep better. In fact, moderate exercise during the treatment phase can alleviate physical pain and eliminate the need for anti-depressants or anti-anxiety medications.

Empowerment

    For most people, undergoing cancer treatment means losing control and power over their own body. Fitness programs, whether they involve gentle stretching movements or more involved exercise, serve to empower cancer survivors.

Motivation

    Motivation is a huge benefit of cancer wellness programs. When cancer patients are motivated to participate in exercise and meditation, they are typically motivated to continue their cancer treatment. They are more inspired and motivated in life, in general, which helps in the recovery process.

Balance

   Many people who managed to maintain physical fitness before cancer are surprised to learn they have lost their sense of balance during treatment. Wellness programs help them find that balance. Classes generally involve balance work and core strength, as well as cardio work and other strengthening exercises. Meditation and affirmation help patients stay focuses and grounded.

According to the National Cancer Institute, physical activity can reduce the risk for developing cancer. Colorectal cancer is one of the more extensively studied cancers with regard to exercise. But fitness is important for people with all cancer types, including endometrial, prostate, mesothelioma, and lung cancers.

Cancer patients are encouraged to stay active between fitness classes, and to continue their exercise work at home. Not only do cancer wellness programs strengthen patients physically, but they also provide emotional and spiritual strength. They also give patients a sense of belonging, so they know they are not alone.


By:
Guest Blogger
David Haas
http://www.mesothelioma.com/blog

Happy 7th Birthday, World Community Grid!

World Community Grid is 7 years of age today, November 16, 2011, and kudos go to all of our members for donating their computer power each and every day to advance critical humanitarian research!

Since last year, we have accomplished the following:

Looking at the numbers: The following statistical growth was accomplished. (To see the current statistics click here).

Members: 44,000 new members registered

Devices: 241,000 new devices were registered

Computer Run Time: 120,000 years of computer run time were donated

Points: 121 Billion points were awarded

Research Results: 243 Million results were returned

Active Research Projects:
During the last 12 months, World Community Grid continued running the following research projects. Click on the project name to find out more about each project:

Drug Search for Leishmaniasis

Computing for Clean Water

The Clean Energy Project - Phase 2

Discovering Dengue Drugs - Together - Phase 2

Help Cure Muscular Dystrophy - Phase 2

Help Fight Childhood Cancer

Help Conquer Cancer

Human Proteome Folding - Phase 2

FightAIDS@Home

New Research Projects:
During the last 12 months, World Community Grid launched the following research projects. Click on the project name to find out more about each project:

GO Fight Against Malaria

Drug Search for Leishmaniasis

Future project queue:
Proposals for nine additional research projects have been received and are being reviewed at this time. Two of these research projects were announced in a September 7, 2010 press release. The remainder of the projects in review will be announced at launch time.

Additional accomplishments:
The following is a list of additional accomplishments:

World Community Grid recognized as one of IBM's 100 Icons of Progress

World Community Grid research scientists awarded portion of IBM Watson Jeopardy! winnings

Expanded ability to handle growth by taking advantage of the IBM SmartCloud Enterprise

30 Peer Reviewed Research Papers

27 World Community Grid Videos

4 Lecture Series Webcasts:

• Discovering Dengue Drugs Together
• FightAIDS@Home
• Human Proteome Folding
• The Clean Energy Project 

Read more...

New World Community Grid project: Go fight against Malaria.

Mission
The mission of the GO Fight Against Malaria project is to discover promising drug candidates that could be developed into new drugs that cure drug resistant forms of malaria. The computing power of World Community Grid will be used to perform computer simulations of the interactions between millions of chemical compounds and certain target proteins, to predict their ability to eliminate malaria. The best compounds will be tested and further developed into possible treatments for the disease.

Significance
Malaria is one of the three deadliest infectious diseases on earth and is caused by parasites that infect both humans and animals. Female mosquitoes spread the disease by biting infected hosts and passing the parasites to other hosts that they bite later. When these parasites replicate themselves in red blood cells (which the parasites use for food), the symptoms of malaria appear. Malaria initially causes fevers and headaches, and in severe cases it leads to comas or death. Plasmodium falciparum, the parasite that causes the deadliest form of malaria, kills more people than any other parasite on the planet. Over 3 billion people are at risk of being infected with malaria.

Although there are many approved drugs that are able to cure malarial infections, multi-drug-resistant mutant "superbugs" exist that are not eliminated by the current drugs. Because new mutant superbugs keep evolving and spreading throughout the world, discovering and developing new types of drugs that can cure infections by these multi-drug-resistant mutant strains of malaria is a significant global health priority.

Approach
Scientists at The Scripps Research Institute of La Jolla, California, U.S.A., will use IBM's World Community Grid to computationally evaluate millions of candidate compounds against different molecular drug targets from the malaria parasite. If these target molecules can be disabled, then patients infected with malaria can potentially be cured. The computations will estimate the ability of the candidate compounds to disable the particular target molecules needed by the malaria parasite to survive and multiply. Particular priority will be given to targets and candidate compounds which could attack the multi-drug-resistant mutant "superbug" strains of the malaria parasite. The power of World Community Grid can reduce to one (1) year what would take at least one hundred (100) years to complete using the resources normally available to the researchers at The Scripps Research Institute. The results computed on World Community Grid will be available in the public domain for all scientists to use and build upon in their research to develop drugs to fight malaria.

Two weeks with FX-8120 Bulldozer and Corsair H100

   Almost two weeks with FX-8120 Bulldozer and Corsair H100 now.
I have been running Boinc 24/7 with 100% usage for FX-8120,AMD Powercolor 6870 and Nvidia Palit GTX 460 1gb. World Community Grid with Cpu, Moo!wrapper with AMD Powercolor 6870 and Primegrid with Nvidia Palit GTX 460 1gb. Just smooth crunching and I can use internet,Youtube and do all the things i usually do, even PC is crunching Boinc tasks with 100% system usage.

    Corsair H100 does good job keeping FX-8120 temps down. I replaced Corsair H100 original fans with two Scythe Gentle Typhoon 1850 rpm fans, because of the noise original fans made and did see temps drop 2 C with Scythe Gentle Typhoons as well.
While crunching no cpu related temperature have past 53 C/127 F. Note: FX-8120 is overclocked to 4 Ghz with two overclocked Gpus with 100% usage in not so big Xigmatek Midgard Midi case. System is powered by very solid and silent PSU Thermaltake ToughPower XT 775W . Motherboard is Gigabyte GA-970A-UD3 and Gigabyte motherboards are perfect with good VRM.

Here is a good review from Corsair H100

My efforts against Childhood Cancer Team is advancing in Boinc Finnish Team standings!

My efforts against Childhood Cancer Team is in 7th place in Boinc Finnish team standings and we are gaining 6th place team fast.

Check out our team stats HERE!

Thank you to our members and happy crunching for a good cause.

LTDAkiles
Email: Akiles@windowslive.com

One way to make world better place for our kids.

Easiest way to help scientist reaserch important projects like Help fight childhood cancer or conquer cancer is to join Boinc Grid Computing.
Grid Computing  is basically an oversized networked computer that allows a problem to be split into thousands of little problems and hundreds of computer’s (home pc’s, laptops, anything except mobile devices). By distributing an enormous problem to many systems, it can be solved faster and more accurately than relying on a single system to tackle the computations involved.


Use the idle time on your computer (Windows, Mac, or Linux) to cure diseases, study global warming, discover pulsars, and do many other types of scientific research. It's safe, secure, and easy:

1. Download and run BOINC software
2. Enter an email address and password. 
3. Once Boinc software is running choose advanced view.
4.  Go to Tools and choose add project.
5.  Choose Project interesting you and add your email and create a password as new user.
6.  Now Boinc starts to download a workunit for your pc to calculate and you are directed to projects your profile page asking your country and Team. To the team spot add "My efforts against childhood cancer". If some projects don't have a team option here, you can see "Find a team" spot page which comes after you have saved your alias.
7. Now you are in your profile page of project of your choosing. You can setup how your's is beeing used,when,how much and how many cores/gpus. You can leave those alone if it's all new to you.
8.  You're done. Just let your computer do it's job and remember Boinc doesn't continue crunching if you close Boinc manager software. So leave it on. You can follow your stats from projects your profile page and http://boincstats.com/ with user search to see all stats from all of your projects.

You can run BOINC while you are chatting, watching movies or web surfing.

Docking@Home

Docking@Home is a project which uses Internet-connected computers to perform scientific calculations that aid in the creation of new and improved medicines. The project aims to help cure diseases such as Human Immunodeficiency Virus (HIV). Docking@Home is a collaboration between the University of Delaware, The Scripps Research Institute, and the University of California - Berkeley. It is part of the Dynamically Adaptive Protein-Ligand Docking System project and is supported by the National Science Foundation.

How Does It Work?

Before new drugs can be produced for laboratory testing, researchers must create molecular models and simulate their interactions to reveal possible candidates for effective drugs. This simulation is called docking. The combinations of molecules and their binding orientations are infinite in number. Simulating as many combinations as possible requires a tremendous amount of computing power. In order to reduce costs, researchers have decided that an effective means of generating this computing power is to distribute the tasks across a large number of computers.

How Can I Help?

By downloading a free program developed at University of California - Berkeley called BOINC, you can contribute your computer's idle processing cycles to the Docking@Home project. It's safe, easy to setup, and runs only when you want it to so it won't affect your ability to use your computer. If you are interested in finding out more information, you can read more about the project and the science behind it, or if you are ready to help, you can GET STARTED .

Docking@Home Staff

Papers

First 24 hours with AMD "Bulldozer" FX-8120

   Monday afternoon i got AMD "Bulldozer" FX-8120, finally. Almost 3 weeks waiting cpus arrive to importers and it's finally up and crunching.  Corsair H100 (CDON.FI sells it for 87€) takes care of cooling the beast. Corsair H100 is one of the best cooling units in the market and i have tested it with 24/7 Boinc crunching with cpu(AMD Phenom II 1055T and from Monday FX-8120) and two gpus(Powercolor 6870 and Palit GTX460 1gb) 100% usage around the clock. There is alot of heat generated in the Xigmatek Midgard case. Corsair H100 and  six Scythe Gentle Typhoons 1850 rpm fans are doing excellent job with cooling.

   Overclocking is fun with "Bulldozer". So much tweaking and testing. I love this cpu. With stock voltages 4.0ghz. Only issue i am having is with APM dropping multiple to 14 with benchmarks like Cinebench , Prime95, OCCT, GeekBench and Linx. Issue only happens when stressing all 8 cores to 100% usage with single multihreaded software. If i run 8 times memtest with 100% core usage to all cores or running 8 boinc cpu tasks multiplier doesn't drop and i am getting 100% performance out from Bulldozer. Gigabyte GA-970A-UD3 bios doesn't have any options in it to disable APM function. I have to wait for new Bios and hope Gigabyte adds APM option to it.

   I will continue with my Overclocking experiments once i have my time.

Poem@Home Gpu support!

From Poem@Home:

We will release a new client by the end of next week. This client will be incompatible with the current client. Therefore we will starve the server of workunits the next week. Starting Monday no new workunits will be generated. We will then take the server offline on Friday to do a server upgrade to enable GPU client compatibility. This release will still be without GPU support. We expect the GPU support to be ready hopefully one week after.

By joining this project you will contribute to a computational approach to

• predict the biologically active structure of proteins
• understand the signal-processing mechanisms when the proteins interact with one another
• understand diseases related to protein malfunction or aggregation
• develop new drugs on the basis of the three-dimensions structure of biologically important proteins.

GPU support in World Community Grid entering Beta in January!

   GPU support in World Community Grid entering Beta in January.

   The September 2011 update to the Help Conquer Cancer project has been posted. In this update, we announce work presented earlier this year at the High-Performance Computing Symposium in Montreal: the development of an OpenCL (GPU) implementation of HCC. This GPU version is currently running in our lab. We are pleased with its performance, and anticipate its eventual launch on the World Community Grid.


From: World Community Grid Help Conquer Cancer forum

Project of the month is World Community Grid

   
   Project for upcoming month is World Community Grid.

 Projects inside World Community Grid are:

- Help Fight Childhood Cancer

- Help Conquer Cancer

- Human Proteome Folding

- FightAIDS@Home

- Drug Search for Leishmaniasis

- Computing for Clean Water

- The Clean Energy Project - Phase 2

- Help Cure Muscular Dystrophy - Phase 2

   You can join World Community Grid here: Click
Once you have everything running Join "My efforts against childhood cancer" team.
You can join our team by logging in to your World community grid profile at WCG homapage"click here" and in your profile "find a team" and search with "My efforts against childhood cancer" or use this link to our teampage "Click"

   For those with Gpus:
Milkyway@home for AMD Gpus and Gpugrid.net for Nvidia gpus.

Dnetc@Home is closed

Dnetc@Home project have been closed.
Read more from Dnetc@home website


Don't worry there is another project running with same goals as Dnetc@home.
Project is Moo!Wrapper . Same applications for same hardware(gpus,cpus) with Dnetc@home and same points.

There's always Milkyway@Home for AMD 48xx,58xx,69xx series gpus.
For Nvidia gpus GpuGrid and Primegrid.

Milkyway@Home uses the BOINC platform to harness volunteered computing resources, creating a highly accurate three dimensional model of the Milky Way galaxy using data gathered by the Sloan Digital Sky Survey. This project enables research in both astroinformatics and computer science.


GpuGrid : is a novel distributed supercomputing infrastructure made of many NVIDIA graphics cards joined together to deliver high-performance all-atom biomolecular simulations.Running GPUGRID on GPUs innovates volunteer computing by delivering supercomputing class applications on a cost effective infrastructure which will greatly impact the way biomedical research is performed.

PrimeGrid : 
PrimeGrid's primary goal is to bring the excitement of prime finding to the "everyday" computer user. By simply downloading and installing BOINC and attaching to the PrimeGrid project, participants can choose from a variety of prime forms to search. With a little patience, you may find a large or even record breaking prime and enter into Chris Caldwell's The Largest Known Primes Database as a Titan!
PrimeGrid's secondary goal is to provide relevant educational materials about primes. Additionally, we wish to contribute to the field of mathematics.
Lastly, primes play a central role in the cryptographic systems which are used for computer security. Through the study of prime numbers it can be shown how much processing is required to crack an encryption code and thus to determine whether current security schemes are sufficiently secure.

Waiting for AMD FX-8120 and Corsair H100 Liquid CPU Cooler to arrive.

  Waiting for missing parts to arrive. Corsair H100 Liquid Cpu Cooler is on it's way and should arrive in next 2 days, but no AMD FX-8120 "Bulldozer" cpus have arrived to importers so far. Can't wait to get new Boinc Cruncher tested, tweaked and crunching for a good cause.

New parts for Boinc Crunchers!!

Yesterday i decided to install new upgrades to Boinc Crunchers.

BoincOne: got Gigabyte GA-970A-UD AM3+ motherboard with old PII x6 1055T@3.85ghz,2x2gb ddr3 Kingston HyperX@1720mhz,Intel 40gb SSD,AMD5830 and NEW Evga GTX 460, Thermaltake ToughPower XT 775W,Scythe Mugen b 2 and Xigmatek Midgard with 6 Scythe Gentle Typhoons.

BoincTwo: Got the old Crossfire Asus mobo with Athlon x3@x4,2x2gb ddr3 Kingston, Amd 6870+4850, Corsair TX650

Boinc3: Asus motherboard,Amd 4850,2x1gb ddr3,Modecon 620W. Once Bulldozer is released this rig will get Athlon x3@x4 and Bulldozer goes to main rig and PII x6 goes to BoincerTwo .

  Needed to install Windows 7 all over again. Guess what, it took 10 times before it did go without any issues with the installation. All kinds of errors and everything did go wrong. Well once i ran installation with minimum parts i got it to work. Not sure what was that all about, but i think Gigabyte motherboard didn't like my AMD 5830 that much. I lost 500gb harddisc in process. Just won't spin anymore.

Btw took me all day yesterday to get rigs working :D

Docking@Home: Creating new and improved medicines

Docking@Home is a project which uses Internet-connected computers to perform scientific calculations that aid in the creation of new and improved medicines. The project aims to help cure diseases such as Human Immunodeficiency Virus (HIV). Docking@Home is a collaboration between the University of Delaware, The Scripps Research Institute, and the University of California - Berkeley. It is part of the Dynamically Adaptive Protein-Ligand Docking System project and is supported by the National Science Foundation.

How Does It Work?

Before new drugs can be produced for laboratory testing, researchers must create molecular models and simulate their interactions to reveal possible candidates for effective drugs. This simulation is called docking. The combinations of molecules and their binding orientations are infinite in number. Simulating as many combinations as possible requires a tremendous amount of computing power. In order to reduce costs, researchers have decided that an effective means of generating this computing power is to distribute the tasks across a large number of computers.

How Can I Help?

By downloading a free program developed at University of California - Berkeley called BOINC, you can contribute your computer's idle processing cycles to the Docking@Home project. It's safe, easy to setup, and runs only when you want it to so it won't affect your ability to use your computer. If you are interested in finding out more information, you can read more about the project and the science behind it, or if you are ready to help, you can get started below.

Welcome Two new Members to My efforts against childhood cancer Team!!

Today we have received two new members to our Boinc team.

Once again welcome!
LTDAkiles
My efforts against childhood cancer Team

Next project of the month: MilkyWay@home

Milkyway@Home uses the BOINC platform to harness volunteered computing resources, creating a highly accurate three dimensional model of the Milky Way galaxy using data gathered by the Sloan Digital Sky Survey. This project enables research in both astroinformatics and computer science.

In computer science, the project is investigating different optimization methods which are resilient to the fault-prone, heterogeneous and asynchronous nature of Internet computing; such as evolutionary and genetic algorithms, as well as asynchronous newton methods. While in astroinformatics, Milkyway@Home is generating highly accurate three dimensional models of the Sagittarius stream, which provides knowledge about how the Milky Way galaxy was formed and how tidal tails are created when galaxies merge.

Milkyway@Home is a joint effort between Rensselaer Polytechnic Institute's departments of Computer Science and Physics, Applied Physics and Astronomy.

World Community Grid : Help Fight Childhood Cancer

Mission
The mission of the Help Fight Childhood Cancer project is to find drugs that can disable three particular proteins associated with neuroblastoma, one of the most frequently occurring solid tumors in children. Identifying these drugs could potentially make the disease much more curable when combined with chemotherapy treatment.


Significance
Neuroblastoma is one of the most common tumors occuring in early childhood and is the most common cause of death in children with solid cancer tumors. If this project is successful, it could dramatically increase the cure rate for neuroblastoma, providing the breakthrough for this disease that has eluded scientists thus far.


Approach
Proteins (molecules which are a bound collection of atoms) are the building blocks of all life processes. They also play an important role in the progress of diseases such as cancer.

Scientists have identified three particular proteins involved with neuroblastoma, which if disabled, could make the disease much more curable by conventional methods such as chemotherapy. This project is performing virtual chemistry experiments between these proteins and each of the three million drug candidates that scientists believe could potentially block the proteins involved. A computer program called AutoDock will test if the shape of the protein and shape of each drug candidate fit together and bond in a suitable way to disable the protein.

This work consists of 9 million virtual chemistry experiments, each of which would take hours to perform on a single computer, totaling over 8,000 years of computer time. World Community Grid is performing these computations in parallel and is thus speeding up the effort dramatically. The project is expected to be completed in two years or less.

You can help by joining and crunching as much as you want.
World Community Grid

New Gpu for Boinc crunching have arrived ! Powercolor 6870

   Finally today i received new GPU for Boinc crunching.
It's Powercolor AMD 6870 1gb and i will install it to Boinc rig Two for Dnetc crunching. It should get about 220K-240K ppd (220 000-240 000 points per day). Before this latest addition my crunchers generated 400K ppd (400 000 points per day). This new gpu should give nice points per day boost to "My efforts against Childhood Cancer" Boinc Team.

SIMAP (Similarity Matrix of Proteins)

SIMAP (Similarity Matrix of Proteins) is a public database of pre-calculated protein similarities that plays a key role in many bioinformatics methods. Protein sequence comparison is the most powerful tool in computational biology for characterizing protein sequences because of the enormous amount of information that is preserved throughout the evolutionary process.

About SIMAP (Similarity Matrix of Proteins) 
The SIMAP database contains all currently published protein sequences and is continuously updated. The computational effort for keeping SIMAP up-to-date is constantly increasing. Please help to update SIMAP by calculating protein similarities on your computer. The computing power you donate supports manifold biological research projects that make use of SIMAP data.

Protein similarities are computed using the FASTA algorithm which provides optimal speed and sensitivity. Protein domains are calculated using the InterPro methods and databases. SIMAP is, to our knowledge, the only project that combines comprehensive coverage with respect to all known proteins and incremental update capabilities.

What is SIMAP used for?
Because of the huge amount of known protein sequences in public databases it became clear that most of them will not be experimentally characterized in the near future. Nevertheless, proteins that have evolved from a common ancestor often share same functions (so-called orthologs). So it is possible to infer the function of a non-characterized protein from an ortholog with known function. A well-known example is the investigations about mouse genes and proteins. Their results are also true for orthologous human genes and proteins in many cases. Protein similarities provide information about relationships between proteins and are necessary for the prediction of orthologs.

Protein domains (often called function domains) are the structural building blocks of proteins. They are responsible for the activities of a certain protein, e.g. binding of small molecules, catalytic reactions or binding other proteins in large complexes. The knowledge about protein domains is stored in huge repositories like the InterPro databases. The prediction of domains in newly sequenced proteins is based on those databases and provides a fully automatic functional annotation of these proteins. Therefore we calculate protein domains for all proteins in SIMAP, thus providing the largest system for protein function prediction worldwide.

There are many more bioinformatics methods that rely on protein similarity and domains. Our protein similarity database provides pre-computed similarity, domain data and represents the known protein space. This opens completely new perspectives compared to the commonly used method to repeatedly re-calculate such kind of data. SIMAP is regularly updated. The similarity matrix is simply being incrementally extended if new sequences occur. The use of SIMAP is completely free for education and public research.
 
Why do we need distributed computing for SIMAP?
The computational costs to calculate the similarity data depend on the square of the number of contained sequences. So the computational effort for keeping the matrix up-to-date is constantly increasing. Our internal resources that perform calculations for SIMAP for the last number of years are no longer sufficient to keep track of all new sequences. That's why we implemented a SIMAP-client for the BOINC platform (Berkeley Open Infrastructure for Network Computing) which is based on the FASTA algorithm to detect sequence similarities.The situation for proteins domains is different but of similar complexity. The computational costs are proportional to the number of sequences and the number of domain models. Due to the growth of the sequence space and the frequent updates in the domain databases, the computational effort for keeping the domain predictions up-to-date is constantly increasing.

What are the institutions behind SIMAP?
SIMAP is a joint project of the GSF National Research Center for Environment and Health, Neuherberg and Technical University Munich, Center of Life and Food Science Weihenstephan (both in Germany). Please contact Thomas Rattei (Department of Genome Oriented Bioinformatics, TU Munich).

Help Fight Childhood Cancer update!!

After screening 3,000,000 candidate chemicals by molecular imaging and cellular toxicity, our project team has finally identified 7 small chemical compounds which kill several neuroblastoma cells at very low concentration.

These compounds are currently subjected for further analyses including the toxicity test using mice as well as elucidation of the molecular mechanism how cancer cells are killed.

From: Help Fight Childhood Cancer at World Commynity Grid

My efforts against Childhood Cancer Rigs!

Boinc One:
Xigmatek Midgard,
AMD Phenom II x6 3.85GHZ,
8 gb ddr3,Intel 40gb Ssd,
AMD 5830 1gb, AMD 4850 1gb,
M4A785TD-V Evo,
Thermaltake 775 Toughpower XT
Mugen 2 B with push 2100 rpm slipstream, pull 1850 rpm Gentle Typhoon and
5x1850 rpm Gentle Typhoons in the case.

Boinc Two:

Basic mid tower case
AMD Athlon x3 one core unlocked to x4 3.2ghz
2x1gb ddr3, AMD 4850 512mb, Asus 760G Mobo
Xilence heatpipe cooler
1850 rpm Gentle Typhoon and Xigmatek 120 case fan
Modecon 620W PSU





Boinc 3 is almost ready. Just need Cpu and Mobo.

New cruncher: 

Amd Athlon x3 with +1 core unlocked to x4, 2x1gb ddr3, Asus 760G motherboard, Modecon 620W powersupply.
I did some finetuning and underclocked 500 mhz from CPU to get CPU Vcore low as possible to get better wattage vs. crunching power ratio. Will save money in running costs and environment.

Amd Phenom 1050 x6 got the Amd 5830 and is crunching Milkyway@home. I have 2 more pci-e x16 and 3xpci-e x1 slots to fill with crunching GPU's. Once i get pci-e x16 slots filled i will use dremel and open up pci-e x1 slots right side ends and install 4850's to crunch. Seen many people to do that and i will try that too :)

All My CPU's crunch World Community Grid and Gpu's Milkyway@Home

New hardware and crucher for World Community Grid online soon.

New hardware and crucher for World Community Grid is online soon.

 Just doing some finetuning and still waiting for Gpu to arrive.
Trying to get vcore low as possible to save some electricity and € in the long run (trust me these things matter).

Gpu should arrive next week and i was thinking about Milkyway@home or trying Folding@Home again with AMD 5830. See if F@H have had progress with new AMD client cores and more out off AMD DP GPU'S.
Once everything is running i will add photos from the casing. I will let children draw something nice.

Help solving the world's energy crisis with EDGeS@Home

Producing energy in a sustainable, safe and  environmental friendly way is one of the main challenges of our time. 

Nuclear Fusion is one of the promising energy sources, but  the technology is difficult to master.  It could provide endless energy - estimated to be sufficient  for  about 2 billion years, there is no CO2  produced and no nuclear waste. Fusion reactors are also inherently safe, because the reaction automatically stops when something goes wrong.

Currently Europe, and other countries from all over the world are working together to develop and  build  nuclear fusion reactors. To predict and optimise the behaviour of nuclear fusion reactions in these  machines, a lot of computer calculations are needed.  Everyone can now help with solving this problem by donating unused computing time to the  EDGeS@Home project. The otherwise wasted computing time can then be used by scientists in Europe to run software called ISDEP  designed to do part of these reactor simulations. ISDEP has been ported by the EDGeS project to the EDGeS infrastructure and is used in EDGeS@Home. In this straightforward way, this ‘green’ approach of information technology and computation make the Fusion research itself environmental friendly now.

From: EDGeS